RGX-104 free Acid( —— )

Catalog No. M21011 CAS No. 610318-54-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RGX-104 free Acid
Note

Research use only, not for human use.
Brief Description

RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)?.
Description

RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)?.
In Vitro

——
In Vivo

Animal Model:NOD SCID or RAG mice injected with 1×106 SKOV3 ovarian cancer cells.Dosage:100 mg/kg.Administration:Oral administration daily for about 60 days.Result:Robustly suppressed tumor growth and progression.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

LXRβ
Research Area

Cancer
Indication

Lymphoma; Solid tumours

CAS Number

610318-54-2
Formula Weight

596.08
Molecular Formula

C34H33ClF3NO3
Purity

>98% (HPLC)
Solubility

DMSO:130 mg/mL (218.09 mM)
SMILES

C[C@H](CCOc1cccc(CC(=O)O)c1)N(Cc1cccc(C(F)(F)F)c1Cl)CC(c1ccccc1)c1ccccc1
Chemical Name

——

1.Tavazoie M F Pollack I Tanqueco R et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer[J]. Cell 2018:S0092867417315064.

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